Reduction of oxidative stress suppresses poly-GR-mediated toxicity in zebrafish embryos

The hexanucleotide (G(4)C(2))-repeat expansion in the C9ORF72 gene is the most common pathogenic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This repeat expansion can be translated into dipeptide repeat proteins (DPRs), and distribution of the poly-GR DPR correlat...

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Detalles Bibliográficos
Autores principales: Riemslagh, Fréderike W., Verhagen, Rob F. M., van der Toorn, Esmay C., Smits, Daphne J., Quint, Wim H., van der Linde, Herma C., van Ham, Tjakko J., Willemsen, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649169/
https://www.ncbi.nlm.nih.gov/pubmed/34693978
http://dx.doi.org/10.1242/dmm.049092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649169/
https://www.ncbi.nlm.nih.gov/pubmed/34693978
http://dx.doi.org/10.1242/dmm.049092

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