Systematic profiling of temperature- and retinal-sensitive rhodopsin variants by deep mutational scanning

Membrane protein variants with diminished conformational stability often exhibit enhanced cellular expression at reduced growth temperatures. The expression of “temperature-sensitive” variants is also typically sensitive to corrector molecules that bind and stabilize the native conformation. There a...

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Detalles Bibliográficos
Autores principales: McKee, Andrew G., Kuntz, Charles P., Ortega, Joseph T., Woods, Hope, Most, Victoria, Roushar, Francis J., Meiler, Jens, Jastrzebska, Beata, Schlebach, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649220/
https://www.ncbi.nlm.nih.gov/pubmed/34756884
http://dx.doi.org/10.1016/j.jbc.2021.101359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649220/
https://www.ncbi.nlm.nih.gov/pubmed/34756884
http://dx.doi.org/10.1016/j.jbc.2021.101359

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