Exclusive inhibition of IL-6 trans-signaling by soluble gp130(FlyR)Fc

gp130 is the signal-transducing receptor for the Interleukin (IL)-6 type cytokines IL-6 and IL-11. To induce signaling, IL-6 forms a complex with IL-6 receptor (IL-6R) and IL-11 with IL-11 receptor (IL-11R). Membrane-bound IL-6R and IL-11R in complex with gp130 and the cytokine mediate classic-signa...

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Detalles Bibliográficos
Autores principales: Berg, Anna F., Ettich, Julia, Weitz, Hendrik T., Krusche, Matthias, Floss, Doreen M., Scheller, Jürgen, Moll, Jens M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649222/
https://www.ncbi.nlm.nih.gov/pubmed/34927050
http://dx.doi.org/10.1016/j.cytox.2021.100058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649222/
https://www.ncbi.nlm.nih.gov/pubmed/34927050
http://dx.doi.org/10.1016/j.cytox.2021.100058

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