Cargando…

Exclusive inhibition of IL-6 trans-signaling by soluble gp130(FlyR)Fc

gp130 is the signal-transducing receptor for the Interleukin (IL)-6 type cytokines IL-6 and IL-11. To induce signaling, IL-6 forms a complex with IL-6 receptor (IL-6R) and IL-11 with IL-11 receptor (IL-11R). Membrane-bound IL-6R and IL-11R in complex with gp130 and the cytokine mediate classic-signa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Berg, Anna F., Ettich, Julia, Weitz, Hendrik T., Krusche, Matthias, Floss, Doreen M., Scheller, Jürgen, Moll, Jens M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649222/ https://www.ncbi.nlm.nih.gov/pubmed/34927050 http://dx.doi.org/10.1016/j.cytox.2021.100058

Ejemplares similares

A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2
por: Ettich, Julia, et al.
Publicado: (2022)

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes
por: Rafii, Puyan, et al.
Publicado: (2023)

Bispecific soluble cytokine receptor-nanobody fusions inhibit Interleukin (IL-)6 trans-signaling and IL-12/23 or tumor necrosis factor (TNF) signaling
por: Gesiorowski, Annika, et al.
Publicado: (2023)

Development and Validation of a Reporter-Cell-Line-Based Bioassay for Therapeutic Soluble gp130-Fc
por: Yu, Lei, et al.
Publicado: (2019)

Interleukin-6 “Trans-Signaling” and Ischemic Vascular Disease: The Important Role of Soluble gp130
por: Morieri, Mario Luca, et al.
Publicado: (2017)

Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice
por: Kammoun, Helene L., et al.
Publicado: (2017)

IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions
por: Floss, Doreen M., et al.
Publicado: (2020)

Respiratory syncytial virus–approved mAb Palivizumab as ligand for anti-idiotype nanobody-based synthetic cytokine receptors
por: Ettich, Julia, et al.
Publicado: (2023)

Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder
por: Szabo, Attila, et al.
Publicado: (2020)

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction
por: Georgy, Jacqueline, et al.
Publicado: (2021)

Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice
por: Hong, Jing, et al.
Publicado: (2016)

The Role of gp130 Cytokines in Tuberculosis
por: Ritter, Kristina, et al.
Publicado: (2020)

GP130 Cytokines in Breast Cancer and Bone
por: Omokehinde, Tolu, et al.
Publicado: (2020)

Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
por: Mossner, Sofie, et al.
Publicado: (2021)

New insights into the role and signalling processes of gp130
por: Rose-John, Stefan
Publicado: (2011)

The two facets of gp130 signalling in liver tumorigenesis
por: Schmidt-Arras, Dirk, et al.
Publicado: (2021)

Role of soluble gp130 in the tumour necrosis factor-alpha expression and its production by peripheral blood mononuclear cells.
por: Jablonskaca, E, et al.
Publicado: (2003)

Forced Homo- and Heterodimerization of All gp130-Type Receptor Complexes Leads to Constitutive Ligand-independent Signaling and Cytokine-independent Growth
por: Suthaus, Jan, et al.
Publicado: (2010)

Synthetic receptor platform to identify loss-of-function single nucleotide variants and designed mutants in the death receptor Fas/CD95
por: Minafra, Anna Rita, et al.
Publicado: (2023)

A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling
por: Lokau, Juliane, et al.
Publicado: (2021)

The Dynamics of Signal Triggering in a gp130-Receptor Complex
por: Matadeen, Rishi, et al.
Publicado: (2007)

Roles of IL-6-gp130 Signaling in Vascular Inflammation
por: Hou, Tieying, et al.
Publicado: (2008)

Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III
por: Corrales-Aguilar, Eugenia, et al.
Publicado: (2014)

Gp130 is expressed in pancreatic cancer and can be targeted by the small inhibitor molecule SC144
por: Pozios, Ioannis, et al.
Publicado: (2022)

Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
por: Luchtefeld, Maren, et al.
Publicado: (2007)

Joint disease caused by defective gp130-mediated STAT signaling
por: Naka, Tetsuji, et al.
Publicado: (2002)

Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy
por: Wei, Jia, et al.
Publicado: (2019)

Structural insights into the assembly of gp130 family cytokine signaling complexes
por: Zhou, Yi, et al.
Publicado: (2023)

IL-6/gp130 signaling: a key unlocking regeneration
por: Li, Ruopu, et al.
Publicado: (2023)

Soluble Interleukin-6 Receptor Induces Motor Stereotypies and Co-Localizes with Gp130 in Regions Linked to Cortico-Striato-Thalamo-Cortical Circuits
por: Patel, Ankur, et al.
Publicado: (2012)

Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway
por: Guerriero, Maria Luisa, et al.
Publicado: (2009)

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model
por: Hatting, M, et al.
Publicado: (2015)

Correction to: Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy
por: Wei, Jia, et al.
Publicado: (2019)

The study of gp130/the inflammatory factors regulating osteoclast differentiation in rheumatoid arthritis
por: Zou, Renling, et al.
Publicado: (2021)

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury
por: Dong, Jinrui, et al.
Publicado: (2022)

Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer
por: Suzuki, Hidetaka, et al.
Publicado: (2022)

gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis
por: Shunkina, Daria, et al.
Publicado: (2023)

Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
por: SOMMER, JAN, et al.
Publicado: (2014)

STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene
por: Kiuchi, Nobuo, et al.
Publicado: (1999)

A role for IL-27p28 as an antagonist of gp130-mediated signaling
por: Stumhofer, Jason S., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_l4jho7sehatsnfoudkbkvppbn5