Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity

Several amyotrophic lateral sclerosis (ALS)-related proteins such as FUS, TDP-43, and hnRNPA1 demonstrate liquid–liquid phase separation, and their disease-related mutations correlate with a transition of their liquid droplet form into aggregates. Missense mutations in SQSTM1/p62, which have been id...

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Detalles Bibliográficos
Autores principales: Faruk, Mohammad Omar, Ichimura, Yoshinobu, Kageyama, Shun, Komatsu-Hirota, Satoko, El-Gowily, Afnan H., Sou, Yu-shin, Koike, Masato, Noda, Nobuo N., Komatsu, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649403/
https://www.ncbi.nlm.nih.gov/pubmed/34774801
http://dx.doi.org/10.1016/j.jbc.2021.101405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649403/
https://www.ncbi.nlm.nih.gov/pubmed/34774801
http://dx.doi.org/10.1016/j.jbc.2021.101405

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