Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice

BACKGROUND: We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in lysosomes, and that this drug decreases atherosclerosis in LDL receptor–deficient mice fed a...

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Detalles Bibliográficos
Autores principales: Ahmad, Feroz, Mitchell, Robert D., Houben, Tom, Palo, Angela, Yadati, Tulasi, Parnell, Andrew J., Patel, Ketan, Shiri‐Sverdlov, Ronit, Leake, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649511/
https://www.ncbi.nlm.nih.gov/pubmed/34493066
http://dx.doi.org/10.1161/JAHA.120.017524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649511/
https://www.ncbi.nlm.nih.gov/pubmed/34493066
http://dx.doi.org/10.1161/JAHA.120.017524

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