Diabetic Aldehyde Dehydrogenase 2 Mutant (ALDH2*2) Mice Are More Susceptible to Cardiac Ischemic‐Reperfusion Injury Due to 4‐Hydroxy‐2‐Nonenal Induced Coronary Endothelial Cell Damage

BACKGROUND: Aldehyde dehydrogenase‐2 (ALDH2), a mitochondrial enzyme, detoxifies reactive aldehydes such as 4‐hydroxy‐2‐nonenal (4HNE). A highly prevalent E487K mutation in ALDH2 (ALDH2*2) in East Asian people with intrinsic low ALDH2 activity is implicated in diabetic complications. 4HNE‐induced ca...

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Detalles Bibliográficos
Autores principales: Pan, Guodong, Roy, Bipradas, Palaniyandi, Suresh Selvaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649540/
https://www.ncbi.nlm.nih.gov/pubmed/34482710
http://dx.doi.org/10.1161/JAHA.121.021140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649540/
https://www.ncbi.nlm.nih.gov/pubmed/34482710
http://dx.doi.org/10.1161/JAHA.121.021140

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