Anti-cancer effects of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives on hepatocellular carcinoma harboring FGFR4 activation

Hepatocellular carcinoma (HCC) is disease with a high mortality rate and limited treatment options. Alterations of fibroblast growth factor receptor 4 (FGFR4) has been regarded as an oncogenic driver for HCC and a promising target for HCC therapeutics. Herein, we report that GNF-7, a multi-targeted...

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Detalles Bibliográficos
Autores principales: Nam, Yunju, Shin, Injae, Kim, Younghoon, Ryu, SeongShick, Kim, Namdoo, Ju, Eunhye, Sim, Taebo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649585/
https://www.ncbi.nlm.nih.gov/pubmed/34864570
http://dx.doi.org/10.1016/j.neo.2021.11.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649585/
https://www.ncbi.nlm.nih.gov/pubmed/34864570
http://dx.doi.org/10.1016/j.neo.2021.11.011

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