Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway

Inhibitors of apoptosis proteins (IAPs) are validated onco-targets, as their overexpression correlates with cancer onset, progression, diffusion and chemoresistance. IAPs regulate cell death survival pathways, inflammation, and immunity. Targeting IAPs, by impairing their protein–protein interaction...

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Detalles Bibliográficos
Autores principales: Cossu, Federica, Camelliti, Simone, Lecis, Daniele, Sorrentino, Luca, Majorini, Maria Teresa, Milani, Mario, Mastrangelo, Eloise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649670/
https://www.ncbi.nlm.nih.gov/pubmed/34938412
http://dx.doi.org/10.1016/j.csbj.2021.11.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649670/
https://www.ncbi.nlm.nih.gov/pubmed/34938412
http://dx.doi.org/10.1016/j.csbj.2021.11.034

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