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Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway
Inhibitors of apoptosis proteins (IAPs) are validated onco-targets, as their overexpression correlates with cancer onset, progression, diffusion and chemoresistance. IAPs regulate cell death survival pathways, inflammation, and immunity. Targeting IAPs, by impairing their protein–protein interaction...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649670/ https://www.ncbi.nlm.nih.gov/pubmed/34938412 http://dx.doi.org/10.1016/j.csbj.2021.11.034 |