Combinatorial Viral Vector-Based and Live Attenuated Vaccines without an Adjuvant to Generate Broader Immune Responses to Effectively Combat Pneumonic Plague

Mice immunized with a combination of an adenovirus vector (Ad5-YFV) and live-attenuated (LMA)-based vaccines were evaluated for protective efficacy against pneumonic plague. While the Ad5-YFV vaccine harbors a fusion cassette of three genes encoding YscF, F1, and LcrV, LMA represents a mutant of par...

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Detalles Bibliográficos
Autores principales: Kilgore, Paul B., Sha, Jian, Hendrix, Emily K., Motin, Vladimir L., Chopra, Ashok K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649767/
https://www.ncbi.nlm.nih.gov/pubmed/34872353
http://dx.doi.org/10.1128/mBio.03223-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649767/
https://www.ncbi.nlm.nih.gov/pubmed/34872353
http://dx.doi.org/10.1128/mBio.03223-21

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