YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In this study, a combination of shRNA‐mediated synthetic lethality screening and transcriptomic analysis revealed the transcription factors YAP/TAZ as key drive...

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Detalles Bibliográficos
Autores principales: Gao, Ruize, Kalathur, Ravi K R, Coto‐Llerena, Mairene, Ercan, Caner, Buechel, David, Shuang, Song, Piscuoglio, Salvatore, Dill, Michael T, Camargo, Fernando D, Christofori, Gerhard, Tang, Fengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649869/
https://www.ncbi.nlm.nih.gov/pubmed/34664408
http://dx.doi.org/10.15252/emmm.202114351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649869/
https://www.ncbi.nlm.nih.gov/pubmed/34664408
http://dx.doi.org/10.15252/emmm.202114351

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