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Tricking enzymes in living cells: a mechanism-based strategy for design of DNA topoisomerase biosensors
Most activity-based molecular probes are designed to target enzymes that catalyze the breaking of chemical bonds and the conversion of a unimolecular substrate into bimolecular products. However, DNA topoisomerases are a class of enzymes that alter DNA topology without producing any molecular segmen...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650243/ https://www.ncbi.nlm.nih.gov/pubmed/34876137 http://dx.doi.org/10.1186/s12951-021-01155-1 |