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CD8+ cell somatic mutations in multiple sclerosis patients and controls—Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies

Somatic mutations have a central role in cancer but their role in other diseases such as common autoimmune disorders is not clear. Previously we and others have demonstrated that especially CD8+ T cells in blood can harbor persistent somatic mutations in some patients with multiple sclerosis (MS) an...

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Detalles Bibliográficos
Autores principales: Valori, Miko, Jansson, Lilja, Tienari, Pentti J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651110/
https://www.ncbi.nlm.nih.gov/pubmed/34874980
http://dx.doi.org/10.1371/journal.pone.0261002