Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity

Severe early-onset obesity is mainly attributed to single gene variations of the hypothalamic leptin-melanocortin system, which is critical for controlling the balance between appetite and energy expenditure. Adenylate cyclase 3 (ADCY3), a transmembrane enzyme localized in primary neuronal cilia, is...

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Detalles Bibliográficos
Autores principales: Toumba, Meropi, Fanis, Pavlos, Vlachakis, Dimitrios, Neocleous, Vassos, Phylactou, Leonidas A., Skordis, Nicos, Mantzoros, Christos S., Pantelidou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651229/
https://www.ncbi.nlm.nih.gov/pubmed/34821371
http://dx.doi.org/10.3892/ijmm.2021.5065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651229/
https://www.ncbi.nlm.nih.gov/pubmed/34821371
http://dx.doi.org/10.3892/ijmm.2021.5065

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