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Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity
Severe early-onset obesity is mainly attributed to single gene variations of the hypothalamic leptin-melanocortin system, which is critical for controlling the balance between appetite and energy expenditure. Adenylate cyclase 3 (ADCY3), a transmembrane enzyme localized in primary neuronal cilia, is...
Autores principales: | Toumba, Meropi, Fanis, Pavlos, Vlachakis, Dimitrios, Neocleous, Vassos, Phylactou, Leonidas A., Skordis, Nicos, Mantzoros, Christos S., Pantelidou, Maria |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651229/ https://www.ncbi.nlm.nih.gov/pubmed/34821371 http://dx.doi.org/10.3892/ijmm.2021.5065 |
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