Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1

The dimeric ER Ca(2+) sensor STIM1 controls store-operated Ca(2+) entry (SOCE) through the regulated binding of its CRAC activation domain (CAD) to Orai channels in the plasma membrane. In resting cells, the STIM1 CC1 domain interacts with CAD to suppress SOCE, but the structural basis of this inter...

Descripción completa

Detalles Bibliográficos
Autores principales: van Dorp, Stijn, Qiu, Ruoyi, Choi, Ucheor B, Wu, Minnie M, Yen, Michelle, Kirmiz, Michael, Brunger, Axel T, Lewis, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651296/
https://www.ncbi.nlm.nih.gov/pubmed/34730514
http://dx.doi.org/10.7554/eLife.66194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651296/
https://www.ncbi.nlm.nih.gov/pubmed/34730514
http://dx.doi.org/10.7554/eLife.66194

Ejemplares similares