Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production

Chronic stress and elevated glucocorticoids (GCs), the major stress hormones, are risk factors for Alzheimer’s disease (AD) and promote AD pathomechanisms, including overproduction of toxic amyloid-β (Aβ) peptides and intraneuronal accumulation of hyperphosphorylated Tau protein. The latter is linke...

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Detalles Bibliográficos
Autores principales: Zhuravleva, Viktoriya, Vaz-Silva, João, Zhu, Mei, Gomes, Patricia, Silva, Joana M., Sousa, Nuno, Sotiropoulos, Ioannis, Waites, Clarissa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651661/
https://www.ncbi.nlm.nih.gov/pubmed/34876559
http://dx.doi.org/10.1038/s41419-021-04433-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651661/
https://www.ncbi.nlm.nih.gov/pubmed/34876559
http://dx.doi.org/10.1038/s41419-021-04433-w

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