Conformational dynamics of free and membrane-bound human Hsp70 in model cytosolic and endo-lysosomal environments

The binding of the major stress-inducible human 70-kDa heat shock protein (Hsp70) to the anionic phospholipid bis-(monoacylglycero)-phosphate (BMP) in the lysosomal membrane is crucial for its impact on cellular pathology in lysosomal storage disorders. However, the conformational features of this p...

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Detalles Bibliográficos
Autores principales: Calvaresi, Valeria, Truelsen, Line T., Larsen, Sidsel B., Petersen, Nikolaj H. T., Kirkegaard, Thomas, Rand, Kasper D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651726/
https://www.ncbi.nlm.nih.gov/pubmed/34876699
http://dx.doi.org/10.1038/s42003-021-02892-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651726/
https://www.ncbi.nlm.nih.gov/pubmed/34876699
http://dx.doi.org/10.1038/s42003-021-02892-7

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