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Conformational dynamics of free and membrane-bound human Hsp70 in model cytosolic and endo-lysosomal environments
The binding of the major stress-inducible human 70-kDa heat shock protein (Hsp70) to the anionic phospholipid bis-(monoacylglycero)-phosphate (BMP) in the lysosomal membrane is crucial for its impact on cellular pathology in lysosomal storage disorders. However, the conformational features of this p...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651726/ https://www.ncbi.nlm.nih.gov/pubmed/34876699 http://dx.doi.org/10.1038/s42003-021-02892-7 |