FLT3-ITD allelic ratio and HLF expression predict FLT3 inhibitor efficacy in adult AML

FLT3 internal tandem duplication (FLT3-ITD) is a frequent mutation in acute myeloid leukemia (AML) and remains a strong prognostic factor due to high rate of disease recurrence. Several FLT3-targeted agents have been developed, but determinants of variable responses to these agents remain understudi...

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Detalles Bibliográficos
Autores principales: Kivioja, Jarno, Malani, Disha, Kumar, Ashwini, Kontro, Mika, Parsons, Alun, Kallioniemi, Olli, Heckman, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651734/
https://www.ncbi.nlm.nih.gov/pubmed/34876631
http://dx.doi.org/10.1038/s41598-021-03010-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651734/
https://www.ncbi.nlm.nih.gov/pubmed/34876631
http://dx.doi.org/10.1038/s41598-021-03010-7

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