A computational approach for the discovery of significant cancer genes by weighted mutation and asymmetric spreading strength in networks

Identifying significantly mutated genes in cancer is essential for understanding the mechanisms of tumor initiation and progression. This task is a key challenge since large-scale genomic studies have reported an endless number of genes mutated at a shallow frequency. Towards uncovering infrequently...

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Detalles Bibliográficos
Autores principales: Cutigi, Jorge Francisco, Evangelista, Adriane Feijo, Reis, Rui Manuel, Simao, Adenilso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651746/
https://www.ncbi.nlm.nih.gov/pubmed/34876593
http://dx.doi.org/10.1038/s41598-021-02671-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651746/
https://www.ncbi.nlm.nih.gov/pubmed/34876593
http://dx.doi.org/10.1038/s41598-021-02671-8

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