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Normalized coefficient of variation (nCV): a method to evaluate circadian clock robustness in population scale data
SUMMARY: Robust oscillation of clock genes is a core feature of the circadian system. Relative amplitude (rAMP) measures the robustness of clock gene oscillations but only works for longitudinal samples. We lack a method for estimating robust oscillations from human samples without labeled time. We...
Autores principales: | Wu, Gang, Francey, Lauren J, Ruben, Marc D, Hogenesch, John B |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652017/ https://www.ncbi.nlm.nih.gov/pubmed/34726689 http://dx.doi.org/10.1093/bioinformatics/btab731 |
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