Thymic Function and T-Cell Receptor Repertoire Diversity: Implications for Patient Response to Checkpoint Blockade Immunotherapy

The capacity of T cells to recognize and mount an immune response against tumor antigens depends on the large diversity of the T-cell receptor (TCR) repertoire generated in the thymus during the process of T-cell development. However, this process is dramatically impaired by immunological insults, s...

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Detalles Bibliográficos
Autores principales: Cardinale, Antonella, De Luca, Carmen Dolores, Locatelli, Franco, Velardi, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652142/
https://www.ncbi.nlm.nih.gov/pubmed/34899700
http://dx.doi.org/10.3389/fimmu.2021.752042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652142/
https://www.ncbi.nlm.nih.gov/pubmed/34899700
http://dx.doi.org/10.3389/fimmu.2021.752042

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