Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity

Background: Doxorubicin (DOX), a broad-spectrum chemotherapy drug, has life-threatening cardiotoxicity. Therefore, searching cardioprotective drugs for DOX-induced cardiotoxicity (DIC) is urgently needed. Objectives: This study aimed to explore cardioprotective effect and specific mechanism by which...

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Detalles Bibliográficos
Autores principales: Li, Weili, Cao, Jing, Wang, Xiaoping, Zhang, Yawen, Sun, Qianbin, Jiang, Yanyan, Yao, Junkai, Li, Chun, Wang, Yong, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652228/
https://www.ncbi.nlm.nih.gov/pubmed/34899332
http://dx.doi.org/10.3389/fphar.2021.773834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652228/
https://www.ncbi.nlm.nih.gov/pubmed/34899332
http://dx.doi.org/10.3389/fphar.2021.773834

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