Cargando…

Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity

Background: Doxorubicin (DOX), a broad-spectrum chemotherapy drug, has life-threatening cardiotoxicity. Therefore, searching cardioprotective drugs for DOX-induced cardiotoxicity (DIC) is urgently needed. Objectives: This study aimed to explore cardioprotective effect and specific mechanism by which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Weili, Cao, Jing, Wang, Xiaoping, Zhang, Yawen, Sun, Qianbin, Jiang, Yanyan, Yao, Junkai, Li, Chun, Wang, Yong, Wang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652228/ https://www.ncbi.nlm.nih.gov/pubmed/34899332 http://dx.doi.org/10.3389/fphar.2021.773834

Ejemplares similares

Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1α-mediated mitochondrial biogenesis
por: Chen, Meicong
Publicado: (2023)

Qishen Granule Protects against Doxorubicin-Induced Cardiotoxicity by Coordinating MDM2-p53-Mediated Mitophagy and Mitochondrial Biogenesis
por: Li, Weili, et al.
Publicado: (2022)

Mechanisms and Drug Intervention for Doxorubicin-Induced Cardiotoxicity Based on Mitochondrial Bioenergetics
por: Ling, Guanjing, et al.
Publicado: (2022)

SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
por: Li, Yuming, et al.
Publicado: (2016)

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
por: Higashida, Kazuhiko, et al.
Publicado: (2013)

Thioredoxin-1 Promotes Mitochondrial Biogenesis Through Regulating AMPK/Sirt1/PGC1α Pathway in Alzheimer's Disease
por: Jia, Jinjing, et al.
Publicado: (2023)

Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy
por: Li, Weili, et al.
Publicado: (2022)

Correction: Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
por: Higashida, Kazuhiko, et al.
Publicado: (2014)

Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro
por: Wang, Xiaoping, et al.
Publicado: (2021)

Basolateral Amygdala SIRT1/PGC-1α Mitochondrial Biogenesis Pathway Mediates Morphine Withdrawal-Associated Anxiety in Mice
por: Yin, Fangyuan, et al.
Publicado: (2022)

Synergistic Effects of Ginsenoside Rb3 and Ferruginol in Ischemia-Induced Myocardial Infarction
por: Chen, Xu, et al.
Publicado: (2022)

miR449a/SIRT1/PGC-1α Is Necessary for Mitochondrial Biogenesis Induced by T-2 Toxin
por: Ma, Shijie, et al.
Publicado: (2018)

ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer
por: Witherspoon, Mavee, et al.
Publicado: (2019)

Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway
por: Han, Xue, et al.
Publicado: (2022)

Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1
por: Wang, Xiaoping, et al.
Publicado: (2019)

Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway
por: Hsu, Hung-Te, et al.
Publicado: (2022)

AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
por: Guo, Sanxing, et al.
Publicado: (2023)

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
por: Guo, Pan, et al.
Publicado: (2014)

Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues
por: Varbanov, Mihayl, et al.
Publicado: (2023)

PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades
por: Liu, Dong, et al.
Publicado: (2019)

Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney
por: Akhtar, Safia, et al.
Publicado: (2019)

Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis
por: Yin, Zhihui, et al.
Publicado: (2021)

Maternal obesity inhibits placental angiogenesis by down-regulating the SIRT1/PGC-1α pathway
por: Peng, Huilin, et al.
Publicado: (2022)

Anti-Zika virus activity of several abietane-type ferruginol analogues
por: Sousa, Francielle T. G., et al.
Publicado: (2020)

Biological Profiling of Semisynthetic C19-Functionalized Ferruginol and Sugiol Analogues
por: González-Cardenete, Miguel A., et al.
Publicado: (2021)

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
por: Fontecha-Barriuso, Miguel, et al.
Publicado: (2020)

Electroacupuncture Upregulates SIRT1-Dependent PGC-1α Expression in SAMP8 Mice
por: Dong, Weiguo, et al.
Publicado: (2015)

Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
por: Bu, Xiaosong, et al.
Publicado: (2017)

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon
por: Li, Lulu, et al.
Publicado: (2016)

Mollification of Doxorubicin (DOX)-Mediated Cardiotoxicity Using Conjugated Chitosan Nanoparticles with Supplementation of Propionic Acid
por: Siva, Durairaj, et al.
Publicado: (2022)

A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy against Breast Cancer and Attenuated Doxorubicin-Induced Cardiotoxicity
por: Geng, Siqi, et al.
Publicado: (2023)

Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2
por: Wang(a), Jie, et al.
Publicado: (2022)

Involvement of the SIRT1/PGC-1α Signaling Pathway in Noise-Induced Hidden Hearing Loss
por: Liu, Yu-Hui, et al.
Publicado: (2022)

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT(2A) receptor and SIRT1–PGC-1α axis
por: Fanibunda, Sashaina E., et al.
Publicado: (2019)

Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway
por: Zou, Runmei, et al.
Publicado: (2023)

Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice
por: Bruynzeel, A M E, et al.
Publicado: (2007)

Anti-herpetic and anti-dengue activity of abietane ferruginol analogues synthesized from (+)-dehydroabietylamine
por: Roa-Linares, Vicky C., et al.
Publicado: (2016)

In Vitro Cytotoxic Effects of Ferruginol Analogues in Sk-MEL28 Human Melanoma Cells
por: Shao, Luying, et al.
Publicado: (2023)

Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease
por: Jiang, Yan, et al.
Publicado: (2021)

PGC-1α is Dispensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle
por: Rowe, Glenn C., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hcg3f2t9ic6vahrfmem8jmmq6b