Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

Disease-modifying therapies, such as neuroprotective and neurorestorative interventions, are strongly desired for Alzheimer’s disease (AD) treatment. Several studies have suggested that histone deacetylase 2 (HDAC2) inhibition can exhibit disease-modifying effects in AD patients. However, whether HD...

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Detalles Bibliográficos
Autores principales: Nakatsuka, Daiki, Izumi, Takaya, Tsukamoto, Tasuku, Oyama, Miki, Nishitomi, Kohei, Deguchi, Yuichi, Niidome, Kazuki, Yamakawa, Hidekuni, Ito, Hisanori, Ogawa, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652290/
https://www.ncbi.nlm.nih.gov/pubmed/34899185
http://dx.doi.org/10.3389/fnmol.2021.782375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652290/
https://www.ncbi.nlm.nih.gov/pubmed/34899185
http://dx.doi.org/10.3389/fnmol.2021.782375

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