Cargando…

Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

Disease-modifying therapies, such as neuroprotective and neurorestorative interventions, are strongly desired for Alzheimer’s disease (AD) treatment. Several studies have suggested that histone deacetylase 2 (HDAC2) inhibition can exhibit disease-modifying effects in AD patients. However, whether HD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakatsuka, Daiki, Izumi, Takaya, Tsukamoto, Tasuku, Oyama, Miki, Nishitomi, Kohei, Deguchi, Yuichi, Niidome, Kazuki, Yamakawa, Hidekuni, Ito, Hisanori, Ogawa, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652290/ https://www.ncbi.nlm.nih.gov/pubmed/34899185 http://dx.doi.org/10.3389/fnmol.2021.782375

Ejemplares similares

Histone Deacetylase Inhibitor Improves the Dysfunction of Hippocampal Gamma Oscillations and Fast Spiking Interneurons in Alzheimer’s Disease Model Mice
por: Takasu, Keiko, et al.
Publicado: (2021)

Dysbindin-1, a Schizophrenia-Related Protein, Functionally Interacts with the DNA- Dependent Protein Kinase Complex in an Isoform-Dependent Manner
por: Oyama, Satoko, et al.
Publicado: (2009)

Knockdown of histone deacetylase 9 attenuates sepsis-induced myocardial injury and inflammatory response
por: Yang, Long, et al.
Publicado: (2023)

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
por: Fiesel, Fabienne C, et al.
Publicado: (2011)

Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory
por: Pandey, Kiran, et al.
Publicado: (2015)

Histone Deacetylase 11 Knockdown Blocks Larval Development and Metamorphosis in the Red Flour Beetle, Tribolium castaneum
por: George, Smitha, et al.
Publicado: (2020)

Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β
por: Yin, Yichen, et al.
Publicado: (2019)

Nucleocytoplasmic Shuttling of Histone Deacetylase 9 Controls Activity-Dependent Thalamocortical Axon Branching
por: Alchini, Ricardo, et al.
Publicado: (2017)

Multiple Invagination Patterns and Synaptic Efficacy in Primate and Mouse Rod Synaptic Terminals
por: Tsukamoto, Yoshihiko, et al.
Publicado: (2022)

The effect of PU.1 knockdown on gene expression and function of mast cells
por: Oda, Yoshihito, et al.
Publicado: (2018)

Pathophysiology and Optimal Treatment of Intracranial Branch Atheromatous Disease
por: Deguchi, Ichiro, et al.
Publicado: (2023)

Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling
por: Granseth, Björn, et al.
Publicado: (2013)

Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models
por: Yokota, Tatsuya, et al.
Publicado: (2018)

Ron Knockdown and Ron Monoclonal Antibody IMC-RON8 Sensitize Pancreatic Cancer to Histone Deacetylase Inhibitors (HDACi)
por: Zou, Yi, et al.
Publicado: (2013)

Histone Deacetylase (HDAC) Inhibitors - Emerging Roles in Neuronal Memory, Learning, Synaptic Plasticity and Neural Regeneration
por: Ahmad Ganai, Shabir, et al.
Publicado: (2016)

Cystotomy with or without fibrinogen clot removal for refractory cystoid macular edema secondary to branch retinal vein occlusion
por: Yamada, Hiroko, et al.
Publicado: (2021)

Efficacy of Treatment with and without Initial Clopidogrel Loading in Branch Atheromatous Disease
por: Deguchi, Ichiro, et al.
Publicado: (2023)

Differentiation of rat adipose tissue-derived stem cells into neuron-like cells by valproic acid, a histone deacetylase inhibitor
por: Okubo, Takumi, et al.
Publicado: (2015)

Differential Expression of Tubulin Acetylase and Deacetylase Between the Damaged Central and Peripheral Branch of Dorsal Root Ganglion Neurons
por: Fu, Zhiyi, et al.
Publicado: (2017)

Functional VEGFA knockdown with artificial 3′-tailed mirtrons defined by 5′ splice site and branch point
por: Kock, Kian Hong, et al.
Publicado: (2015)

Complex regulation of the regulator of synaptic plasticity histone deacetylase 2 in the rodent dorsal horn after peripheral injury
por: Maiarù, Maria, et al.
Publicado: (2016)

Impairment of Coronary Flow Reserve Evaluated by Phase Contrast Cine‐Magnetic Resonance Imaging in Patients With Heart Failure With Preserved Ejection Fraction
por: Kato, Shingo, et al.
Publicado: (2016)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Anti-tumor effects of the histone deacetylase inhibitor vorinostat on canine urothelial carcinoma cells
por: Eto, Shotaro, et al.
Publicado: (2019)

Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion
por: Wang, Wei, et al.
Publicado: (2022)

Knockdown of the Drosophila Fused in Sarcoma (FUS) Homologue Causes Deficient Locomotive Behavior and Shortening of Motoneuron Terminal Branches
por: Sasayama, Hiroshi, et al.
Publicado: (2012)

Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model
por: Zhu, Jun-yi, et al.
Publicado: (2013)

Dendritic Branch Intersections Are Structurally Regulated Targets for Efficient Axonal Wiring and Synaptic Clustering
por: Pinchas, Monika, et al.
Publicado: (2013)

Prognostic value of cardiovascular magnetic resonance derived right ventricular function in patients with interstitial lung disease
por: Kato, Shingo, et al.
Publicado: (2015)

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation
por: Inoue, Eiji, et al.
Publicado: (2009)

Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging
por: Takaya, Kento, et al.
Publicado: (2022)

Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B
por: Sharma, Mahima, et al.
Publicado: (2015)

Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex
por: Basu, Trina, et al.
Publicado: (2019)

Phosphodiesterase-4D Knockdown in the Prefrontal Cortex Alleviates Memory Deficits and Synaptic Failure in Mouse Model of Alzheimer’s Disease
por: Shi, Yongchuan, et al.
Publicado: (2021)

Knockdown of Selenocysteine-Specific Elongation Factor in Amblyomma maculatum Alters the Pathogen Burden of Rickettsia parkeri with Epigenetic Control by the Sin3 Histone Deacetylase Corepressor Complex
por: Adamson, Steven W., et al.
Publicado: (2013)

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
por: Yao, Ya-Li, et al.
Publicado: (2011)

Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
por: Hai, Yang, et al.
Publicado: (2017)

The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord
por: Takeda, Daisuke, et al.
Publicado: (2007)

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation
por: Takahashi, Tetsuyuki, et al.
Publicado: (2014)

Structure of two purple pigments, catechinopyranocyanidins A and B from the seed-coat of the small red bean, Vigna angularis
por: Yoshida, Kumi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ea5hf0g2ugp4o1lbnrf4f90q4q