Cargando…

Expression and function of SLC38A5, an amino acid-coupled Na(+)/H(+) exchanger, in triple-negative breast cancer and its relevance to macropinocytosis

Metabolic reprogramming in cancer necessitates increased amino acid uptake, which is accomplished by up-regulation of specific amino acid transporters. However, not all tumors rely on any single amino acid transporter for this purpose. Here, we report on the differential up-regulation of the amino a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramachandran, Sabarish, R. Sennoune, Souad, Sharma, Monica, Thangaraju, Muthusamy, V. Suresh, Varshini, Sneigowski, Tyler, D. Bhutia, Yangzom, Pruitt, Kevin, Ganapathy, Vadivel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2021
Materias:	Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652584/ https://www.ncbi.nlm.nih.gov/pubmed/34704597 http://dx.doi.org/10.1042/BCJ20210585

Ejemplares similares

Unconventional Functions of Amino Acid Transporters: Role in Macropinocytosis (SLC38A5/SLC38A3) and Diet-Induced Obesity/Metabolic Syndrome (SLC6A19/SLC6A14/SLC6A6)
por: Bhutia, Yangzom D., et al.
Publicado: (2022)

Potent Inhibition of Macropinocytosis by Niclosamide in Cancer Cells: A Novel Mechanism for the Anticancer Efficacy for the Antihelminthic
por: Sennoune, Souad R., et al.
Publicado: (2023)

SLC6A14, a Na(+)/Cl(−)-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling
por: Sikder, Mohd O. F., et al.
Publicado: (2020)

SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine–Glycine–One-Carbon Pathways in Cancer
por: Sniegowski, Tyler, et al.
Publicado: (2021)

Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health
por: Sivaprakasam, Sathish, et al.
Publicado: (2017)

Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer
por: Sniegowski, Tyler, et al.
Publicado: (2023)

RETRACTED ARTICLE: Identification of a novel Na(+)-coupled Fe(3+)-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells
por: Ogura, Jiro, et al.
Publicado: (2018)

Retraction Note: Identification of a novel Na(+)-coupled Fe(3+)-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells
por: Ogura, Jiro, et al.
Publicado: (2018)

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier
por: Kopel, Jonathan J., et al.
Publicado: (2021)

Plasma Membrane Na(+)-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy
por: Bhutia, Yangzom D., et al.
Publicado: (2017)

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate
por: Babu, Ellappan, et al.
Publicado: (2011)

A Proton-Coupled Transport System for β-Hydroxy-β-Methylbutyrate (HMB) in Blood–Brain Barrier Endothelial Cell Line hCMEC/D3
por: Higuchi, Kei, et al.
Publicado: (2021)

The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin
por: Kopel, Jonathan, et al.
Publicado: (2020)

α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice
por: Sivaprakasam, Sathish, et al.
Publicado: (2021)

Sigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis
por: Nguyen, Nhi T., et al.
Publicado: (2023)

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling
por: Sharma, Monica, et al.
Publicado: (2021)

Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer
por: Bhutia, Yangzom D., et al.
Publicado: (2020)

Selenomethionine (Se-Met) Induces the Cystine/Glutamate Exchanger SLC7A11 in Cultured Human Retinal Pigment Epithelial (RPE) Cells: Implications for Antioxidant Therapy in Aging Retina
por: Ananth, Sudha, et al.
Publicado: (2020)

Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine
por: Bhutia, Yangzom D., et al.
Publicado: (2016)

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer
por: Schniers, Bradley K., et al.
Publicado: (2022)

Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu
por: Sivaprakasam, Sathish, et al.
Publicado: (2019)

Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis
por: Ristic, Bojana, et al.
Publicado: (2020)

Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis
por: Arjunan, Pachiappan, et al.
Publicado: (2016)

Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues
por: Mathew, Marilyn, et al.
Publicado: (2023)

Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types
por: Kou, Longfa, et al.
Publicado: (2018)

PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target
por: Schniers, Bradley K., et al.
Publicado: (2021)

Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery
por: Kou, Longfa, et al.
Publicado: (2020)

Binding of Citrate-Fe(3+) to Plastic Culture Dishes, an Artefact Useful as a Simple Technique to Screen for New Iron Chelators
por: Ogura, Jiro, et al.
Publicado: (2022)

Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer
por: Manna, Pulak R., et al.
Publicado: (2023)

A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects
por: Jaramillo-Martinez, Valeria, et al.
Publicado: (2021)

Functional analysis of a species-specific inhibitor selective for human Na(+)-coupled citrate transporter (NaCT/SLC13A5/mINDY)
por: Higuchi, Kei, et al.
Publicado: (2020)

Taurine uptake across the human intestinal brush-border membrane is via two transporters: H(+)-coupled PAT1 (SLC36A1) and Na(+)- and Cl(−)-dependent TauT (SLC6A6)
por: Anderson, Catriona M H, et al.
Publicado: (2009)

Human solute carrier SLC6A14 is the β-alanine carrier
por: Anderson, Catriona M H, et al.
Publicado: (2008)

TBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3p
por: Patel, Girijesh Kumar, et al.
Publicado: (2021)

The Wnt non-canonical signaling modulates cabazitaxel sensitivity in prostate cancer cells
por: Sennoune, Souad R., et al.
Publicado: (2020)

The Genetic Variability of Members of the SLC38 Family of Amino Acid Transporters (SLC38A3, SLC38A7 and SLC38A9) Affects Susceptibility to Type 2 Diabetes and Vascular Complications
por: Crocco, Paolina, et al.
Publicado: (2022)

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
por: Pathania, Rajneesh, et al.
Publicado: (2015)

Metabolic functions of macropinocytosis
por: Palm, Wilhelm
Publicado: (2019)

The origins and evolution of macropinocytosis
por: King, Jason S., et al.
Publicado: (2019)

Ubiquitous macropinocytosis in anthozoans
por: Ganot, Philippe, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t8ns8vq9r46gdj21mf3lrq1kc9