Cargando…

The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines

Rho-associated kinases (ROCK) are a class of serine/threonine kinases that play important roles in various biological processes. ROCK are becoming attractive targets for drug designing. A novel scaffold was designed according to molecular hybridization strategy, then a series of 4-aryl-5-aminomethyl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Linan, Ouyang, Ben, Fan, Meixia, Qi, Junhui, Yao, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shaheed Beheshti University of Medical Sciences 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653655/ https://www.ncbi.nlm.nih.gov/pubmed/34903975 http://dx.doi.org/10.22037/ijpr.2020.114468.14866

Ejemplares similares

Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors
por: Nasli Esfahani, Anita, et al.
Publicado: (2021)

Design, synthesis and fungicidal activity of isothiazole–thiazole derivatives
por: Wu, Qi-Fan, et al.
Publicado: (2018)

Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies
por: Kartsev, Victor, et al.
Publicado: (2022)

Synthesis of N-aryl amines enabled by photocatalytic dehydrogenation
por: Kim, Jungwon, et al.
Publicado: (2020)

Design and Synthesis of New 2-Aryl-4,5-dihydro-thiazole Analogues: In Vitro Antibacterial Activities and Preliminary Mechanism of Action
por: Tan, Fangfang, et al.
Publicado: (2015)

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity
por: Sun, Maolin, et al.
Publicado: (2017)

Aryl Bromides and Aryl Chlorides for the Direct Arylation of Benzylic Amines Mediated by Ruthenium(II)
por: Dastbaravardeh, Navid, et al.
Publicado: (2013)

Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach
por: Min, Chang, et al.
Publicado: (2014)

N-Aryl Lactams by Regioselective Ozonation of N-Aryl Cyclic Amines
por: Saliu, Francesco, et al.
Publicado: (2012)

Facile Conversion of Aryl Amines Having No α-Methylene to Aryl Nitriles
por: Moirangthem, Shyamkanhai S., et al.
Publicado: (2022)

De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis
por: Tatton, Matthew R., et al.
Publicado: (2014)

Facile synthesis of amides via acceptorless dehydrogenative coupling of aryl epoxides and amines
por: Liang, Yaoyu, et al.
Publicado: (2022)

Design, synthesis, and in vitro antitumor activity of 6-aryloxyl substituted quinazoline derivatives
por: FAN, Meixia, et al.
Publicado: (2022)

Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
por: Raghu, M.S., et al.
Publicado: (2023)

Challenging nickel-catalysed amine arylations enabled by tailored ancillary ligand design
por: Lavoie, Christopher M., et al.
Publicado: (2016)

4-(Indol-3-yl)thiazole-2-amines and 4-ιndol-3-yl)thiazole Acylamines as Νovel Antimicrobial Agents: Synthesis, In Silico and In Vitro Evaluation
por: Simakov, Sergei, et al.
Publicado: (2021)

Synthesis and Biological Screening of New 2-(5-Aryl-1-phenyl-1H-pyrazol-3-yl)-4-aryl Thiazole Derivatives as Potential Antimicrobial Agents
por: Nandurkar, Yogesh, et al.
Publicado: (2023)

Photoredox-catalyzed oxo-amination of aryl cyclopropanes
por: Ge, Liang, et al.
Publicado: (2019)

4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile
por: Sharma, Deepika, et al.
Publicado: (2019)

Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines
por: Rzhevskiy, Sergey A., et al.
Publicado: (2019)

An Electron-Transporting Thiazole-Based Polymer Synthesized Through Direct (Hetero)Arylation Polymerization
por: Chávez, Patricia, et al.
Publicado: (2018)

In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
por: Pereira, Adriana S. A., et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of Benzo[D]Thiazole with Dimethylpyrazol Derivatives
por: Liu, Dachuan, et al.
Publicado: (2019)

Buchwald–Hartwig Amination of Aryl Halides with Heterocyclic Amines in the Synthesis of Highly Fluorescent Benzodifuran-Based Star-Shaped Organic Semiconductors
por: Bosiak, Mariusz J., et al.
Publicado: (2021)

Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors
por: Ferreira, Rubén, et al.
Publicado: (2015)

4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
por: Rodrigues, Carina Agostinho, et al.
Publicado: (2018)

Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study
por: Al-Sanea, Mohammad M., et al.
Publicado: (2023)

Thiazole and Oxazole Alkaloids: Isolation and Synthesis
por: Davyt, Danilo, et al.
Publicado: (2010)

Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds
por: Fernández-Salas, José A., et al.
Publicado: (2015)

Tetrabutylammonium Bromide-Promoted Metal-Free, Efficient, Rapid, and Scalable Synthesis of N-Aryl Amines
por: Johnson, Chad R., et al.
Publicado: (2018)

Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and multi-targeting kinase inhibitors
por: Othman, Ismail M. M., et al.
Publicado: (2021)

Convergent synthesis, kinetics insight and allosteric computational ascriptions of thiazole-(5-aryl)oxadiazole hybrids embraced with propanamides as alkaline phosphatase inhibitors
por: Butt, Abdul Rehman Sadiq, et al.
Publicado: (2023)

Mechanochemical Conversion of Aromatic Amines to Aryl Trifluoromethyl Ethers
por: Jakubczyk, Michał, et al.
Publicado: (2022)

Design, and synthesis of selectively anticancer 4-cyanophenyl substituted thiazol-2-ylhydrazones
por: Mehmood, Hasnain, et al.
Publicado: (2022)

Rational Ligand Design for the Arylation of Hindered Primary Amines Guided by Reaction Progress Kinetic Analysis
por: Ruiz-Castillo, Paula, et al.
Publicado: (2015)

4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities
por: Rafinejad, Ali, et al.
Publicado: (2012)

Design, synthesis, and biological evaluation of thiazole/thiadiazole carboxamide scaffold-based derivatives as potential c-Met kinase inhibitors for cancer treatment
por: Nan, Xiang, et al.
Publicado: (2023)

N-(2,4-Dichlorophenyl)-1,3-thiazol-2-amine
por: Babar, Ayesha, et al.
Publicado: (2012)

Synthesis of amantadine clubbed N-aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies
por: Zahra, Fatima Tuz, et al.
Publicado: (2023)

One‐Pot Synthesis of Chiral N‐Arylamines by Combining Biocatalytic Aminations with Buchwald–Hartwig N‐Arylation
por: Cosgrove, Sebastian C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_h2kjbua1q6oj69gj3ovv41majl