A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer

Mutations in the PHIP/BRWD2 chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations in PHIP expression are linked to cancer. Precisely how PHIP functions in these contexts is not fully understood. Here we demonstrate that PHIP is a chromatin-associate...

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Detalles Bibliográficos
Autores principales: Morgan, Marc A.J., Popova, Irina K., Vaidya, Anup, Burg, Jonathan M., Marunde, Matthew R., Rendleman, Emily J., Dumar, Zachary J., Watson, Rachel, Meiners, Matthew J., Howard, Sarah A., Khalatyan, Natalia, Vaughan, Robert M., Rothbart, Scott B., Keogh, Michael-C., Shilatifard, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653789/
https://www.ncbi.nlm.nih.gov/pubmed/34819353
http://dx.doi.org/10.1101/gad.348766.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653789/
https://www.ncbi.nlm.nih.gov/pubmed/34819353
http://dx.doi.org/10.1101/gad.348766.121

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