O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells

Escherichia coli K1 causes bacteremia and meningitis in human neonates. The K1 capsule, an α2,8-linked polysialic acid (PSA) homopolymer, is its essential virulence factor. PSA is usually partially modified by O-acetyl groups. It is known that O-acetylation alters the antigenicity of PSA, but its im...

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Detalles Bibliográficos
Autores principales: Yang, Jinghua, Ma, Wei, Wu, Yuanyuan, Zhou, Hui, Song, Siyu, Cao, Yuqi, Wang, Chengxu, Liu, Xiangyuan, Ren, Jinwei, Duan, Jinyou, Pei, Zhichao, Jin, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653822/
https://www.ncbi.nlm.nih.gov/pubmed/34878295
http://dx.doi.org/10.1128/spectrum.00399-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653822/
https://www.ncbi.nlm.nih.gov/pubmed/34878295
http://dx.doi.org/10.1128/spectrum.00399-21

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