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O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells

Escherichia coli K1 causes bacteremia and meningitis in human neonates. The K1 capsule, an α2,8-linked polysialic acid (PSA) homopolymer, is its essential virulence factor. PSA is usually partially modified by O-acetyl groups. It is known that O-acetylation alters the antigenicity of PSA, but its im...

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Detalles Bibliográficos
Autores principales:	Yang, Jinghua, Ma, Wei, Wu, Yuanyuan, Zhou, Hui, Song, Siyu, Cao, Yuqi, Wang, Chengxu, Liu, Xiangyuan, Ren, Jinwei, Duan, Jinyou, Pei, Zhichao, Jin, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653822/ https://www.ncbi.nlm.nih.gov/pubmed/34878295 http://dx.doi.org/10.1128/spectrum.00399-21

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