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Identifying the true origins of selectivity in chiral phosphoric acid catalyzed N-acyl-azetidine desymmetrizations
The first catalytic intermolecular desymmetrization of azetidines was reported by Sun and coworkers in 2015 using a BINOL-derived phosphoric acid catalyst (J. Am. Chem. Soc. 2015, 137, 5895–5898). To uncover the mechanism of the reaction and the origins of the high enantioselectivity, Density Functi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society of Chemistry
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654023/ https://www.ncbi.nlm.nih.gov/pubmed/35003597 http://dx.doi.org/10.1039/d1sc04969k |