PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells

Non-alcoholic steatohepatitis (NASH) results, in part, from the interaction of metabolic derangements with predisposing genetic variants, leading to liver-related complications and mortality. The strongest genetic determinant is a highly prevalent missense variant in patatin-like phospholipase domai...

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Detalles Bibliográficos
Autores principales: Rady, Brian, Nishio, Takahiro, Dhar, Debanjan, Liu, Xiao, Erion, Mark, Kisseleva, Tatiana, Brenner, David A., Pocai, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654208/
https://www.ncbi.nlm.nih.gov/pubmed/34879108
http://dx.doi.org/10.1371/journal.pone.0260721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654208/
https://www.ncbi.nlm.nih.gov/pubmed/34879108
http://dx.doi.org/10.1371/journal.pone.0260721

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