Structures of neurokinin 1 receptor in complex with G(q) and G(s) proteins reveal substance P binding mode and unique activation features

The neurokinin 1 receptor (NK(1)R) is involved in inflammation and pain transmission. This pathophysiologically important G protein–coupled receptor is predominantly activated by its cognate agonist substance P (SP) but also by the closely related neurokinins A and B. Here, we report cryo–electron m...

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Detalles Bibliográficos
Autores principales: Thom, Cristian, Ehrenmann, Janosch, Vacca, Santiago, Waltenspühl, Yann, Schöppe, Jendrik, Medalia, Ohad, Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654284/
https://www.ncbi.nlm.nih.gov/pubmed/34878828
http://dx.doi.org/10.1126/sciadv.abk2872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654284/
https://www.ncbi.nlm.nih.gov/pubmed/34878828
http://dx.doi.org/10.1126/sciadv.abk2872

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