Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence

Medulloblastoma (MB) remains a leading cause of cancer-related mortality among children. The paucity of MB samples collected at relapse has hindered the functional understanding of molecular mechanisms driving therapy failure. New models capable of accurately recapitulating tumor progression in resp...

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Detalles Bibliográficos
Autores principales: Bakhshinyan, David, Adile, Ashley A., Liu, Jeff, Gwynne, William D., Suk, Yujin, Custers, Stefan, Burns, Ian, Singh, Mohini, McFarlane, Nicole, Subapanditha, Minomi K., Qazi, Maleeha A., Vora, Parvez, Kameda-Smith, Michelle M., Savage, Neil, Desmond, Kim L., Tatari, Nazanin, Tran, Damian, Seyfrid, Mathieu, Hope, Kristin, Bock, Nicholas A., Venugopal, Chitra, Bader, Gary D., Singh, Sheila K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654291/
https://www.ncbi.nlm.nih.gov/pubmed/34878832
http://dx.doi.org/10.1126/sciadv.abi5568

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