Genome-editing prodrug: Targeted delivery and conditional stabilization of CRISPR-Cas9 for precision therapy of inflammatory disease

Regulation of CRISPR-Cas9 functions in vivo is conducive to developing precise therapeutic genome editing. Here, we report a CRISPR-Cas9 prodrug nanosystem (termed NanoProCas9), which combines the targeted delivery and the conditional activation of CRISPR-Cas9 for the precision therapy of inflammato...

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Detalles Bibliográficos
Autores principales: Yan, Xiaojie, Pan, Qi, Xin, Huhu, Chen, Yuxuan, Ping, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654308/
https://www.ncbi.nlm.nih.gov/pubmed/34878850
http://dx.doi.org/10.1126/sciadv.abj0624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654308/
https://www.ncbi.nlm.nih.gov/pubmed/34878850
http://dx.doi.org/10.1126/sciadv.abj0624

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