Cargando…

Genome-editing prodrug: Targeted delivery and conditional stabilization of CRISPR-Cas9 for precision therapy of inflammatory disease

Regulation of CRISPR-Cas9 functions in vivo is conducive to developing precise therapeutic genome editing. Here, we report a CRISPR-Cas9 prodrug nanosystem (termed NanoProCas9), which combines the targeted delivery and the conditional activation of CRISPR-Cas9 for the precision therapy of inflammato...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Xiaojie, Pan, Qi, Xin, Huhu, Chen, Yuxuan, Ping, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654308/ https://www.ncbi.nlm.nih.gov/pubmed/34878850 http://dx.doi.org/10.1126/sciadv.abj0624

Ejemplares similares

Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice
por: Bu, Wen, et al.
Publicado: (2023)

In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy
por: Han, Jeong Pil, et al.
Publicado: (2022)

Comprehensive analysis and accurate quantification of unintended large gene modifications induced by CRISPR-Cas9 gene editing
por: Park, So Hyun, et al.
Publicado: (2022)

Hierarchical self-uncloaking CRISPR-Cas13a–customized RNA nanococoons for spatial-controlled genome editing and precise cancer therapy
por: Fan, Ningke, et al.
Publicado: (2022)

A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing
por: Wang, Yao, et al.
Publicado: (2023)

A temperature-tolerant CRISPR base editor mediates highly efficient and precise gene editing in Drosophila
por: Doll, Roman M., et al.
Publicado: (2023)

An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
por: Hansen, Stine L., et al.
Publicado: (2023)

A far-red light–inducible CRISPR-Cas12a platform for remote-controlled genome editing and gene activation
por: Wang, Xinyi, et al.
Publicado: (2021)

Precise CRISPR-Cas–mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells
por: Tran, Ngoc Tung, et al.
Publicado: (2022)

Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases
por: Wan, Tao, et al.
Publicado: (2022)

A dual-specific CRISPR-Cas nanosystem for precision therapeutic editing of liver disorders
por: Xu, Xiaojie, et al.
Publicado: (2022)

Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy
por: Zou, Yan, et al.
Publicado: (2022)

Targeted gene silencing in the nervous system with CRISPR-Cas13
por: Powell, Jackson E., et al.
Publicado: (2022)

Analysis of bacterial pangenomes reduces CRISPR dark matter and reveals strong association between membranome and CRISPR-Cas systems
por: Rubio, Alejandro, et al.
Publicado: (2023)

CRISPR-Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells
por: Hany, Dina, et al.
Publicado: (2023)

An ultrasound-activatable platinum prodrug for sono-sensitized chemotherapy
por: Liu, Gongyuan, et al.
Publicado: (2023)

Host nucleases generate prespacers for primed adaptation in the E. coli type I-E CRISPR-Cas system
por: Shiriaeva, Anna A., et al.
Publicado: (2022)

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
por: Rais, Rana, et al.
Publicado: (2022)

Heritable Genome Editing with CRISPR/Cas9 in the Silkworm, Bombyx mori
por: Wei, Wei, et al.
Publicado: (2014)

Rational Design of Poly(disulfide)s as a Universal Platform for Delivery of CRISPR-Cas9 Machineries toward Therapeutic Genome Editing
por: Guo, Jiajing, et al.
Publicado: (2021)

Inflammation conditional genome editing mediated by the CRISPR-Cas9 system
por: Yuan, Tingting, et al.
Publicado: (2023)

Inflammation conditional genome editing mediated by the CRISPR-Cas9 system
por: Yuan, Tingting, et al.
Publicado: (2023)

Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
por: Zhang, Song, et al.
Publicado: (2021)

Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing
por: Duan, Li, et al.
Publicado: (2021)

High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing
por: Neil, Kevin, et al.
Publicado: (2021)

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation
por: Bhagchandani, Sachin H., et al.
Publicado: (2023)

CRISPR-based engineering of RNA viruses
por: Nemudryi, Artem, et al.
Publicado: (2023)

An optimized CRISPR/Cas9 approach for precise genome editing in neurons
por: Fang, Huaqiang, et al.
Publicado: (2021)

Approaches to Enhance Precise CRISPR/Cas9-Mediated Genome Editing
por: Denes, Christopher E., et al.
Publicado: (2021)

Off-target effects in CRISPR/Cas9 gene editing
por: Guo, Congting, et al.
Publicado: (2023)

Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine
por: Khoshandam, Mohadeseh, et al.
Publicado: (2023)

Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy
por: Wu, Di, et al.
Publicado: (2022)

Inducible Genome Editing with Conditional CRISPR/Cas9 Mice
por: Katigbak, Alexandra, et al.
Publicado: (2018)

Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes
por: Tang, Mei, et al.
Publicado: (2022)

Precision cancer mouse models through genome editing with CRISPR-Cas9
por: Mou, Haiwei, et al.
Publicado: (2015)

Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system
por: Irion, Uwe, et al.
Publicado: (2014)

Increasing the efficiency of CRISPR‐Cas9‐VQR precise genome editing in rice
por: Hu, Xixun, et al.
Publicado: (2017)

Cloning and base editing of GFP transgenic rhesus monkey and off-target analysis
por: Kang, Yu, et al.
Publicado: (2022)

Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections
por: Paredes-Redondo, Amaia, et al.
Publicado: (2021)

Application of combined CRISPR screening for genetic and chemical-genetic interaction profiling in Mycobacterium tuberculosis
por: Yan, Mei-Yi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_df85k2tb9c5c5ebiqba0hqtp0c