Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al., 2019) that PTCH1 inhibits Smoothened by depl...

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Detalles Bibliográficos
Autores principales: Kinnebrew, Maia, Luchetti, Giovanni, Sircar, Ria, Frigui, Sara, Viti, Lucrezia Vittoria, Naito, Tomoki, Beckert, Francis, Saheki, Yasunori, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654371/
https://www.ncbi.nlm.nih.gov/pubmed/34698632
http://dx.doi.org/10.7554/eLife.70504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654371/
https://www.ncbi.nlm.nih.gov/pubmed/34698632
http://dx.doi.org/10.7554/eLife.70504

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