Evaluation of a 5-HT(2B) receptor agonist in a murine model of amyotrophic lateral sclerosis

Degeneration of brainstem serotonin neurons has been demonstrated in ALS patients and mouse models and was found responsible for the development of spasticity. Consistent with involvement of central serotonin pathways, 5-HT(2B) receptor (5-HT(2B)R) was upregulated in microglia of ALS mice. Its delet...

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Detalles Bibliográficos
Autores principales: Arnoux, Alizée, Ayme-Dietrich, Estelle, Dieterle, Stéphane, Goy, Marc-Antoine, Schann, Stephan, Frauli, Mélanie, Monassier, Laurent, Dupuis, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654833/
https://www.ncbi.nlm.nih.gov/pubmed/34880312
http://dx.doi.org/10.1038/s41598-021-02900-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654833/
https://www.ncbi.nlm.nih.gov/pubmed/34880312
http://dx.doi.org/10.1038/s41598-021-02900-0

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