RGEN-seq for highly sensitive amplification-free screen of off-target sites of gene editors

Sensitive detection of off-target sites produced by gene editing nucleases is crucial for developing reliable gene therapy platforms. Although several biochemical assays for the characterization of nuclease off-target effects have been recently published, significant technical and methodological iss...

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Detalles Bibliográficos
Autores principales: Kuzin, Alexander, Redler, Brendan, Onuska, Jaya, Slesarev, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654851/
https://www.ncbi.nlm.nih.gov/pubmed/34880355
http://dx.doi.org/10.1038/s41598-021-03160-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654851/
https://www.ncbi.nlm.nih.gov/pubmed/34880355
http://dx.doi.org/10.1038/s41598-021-03160-8

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