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RGEN-seq for highly sensitive amplification-free screen of off-target sites of gene editors
Sensitive detection of off-target sites produced by gene editing nucleases is crucial for developing reliable gene therapy platforms. Although several biochemical assays for the characterization of nuclease off-target effects have been recently published, significant technical and methodological iss...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654851/ https://www.ncbi.nlm.nih.gov/pubmed/34880355 http://dx.doi.org/10.1038/s41598-021-03160-8 |