Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening

HIV-1 reverse transcriptase (RT) slides over an RNA/DNA or dsDNA substrate while copying the viral RNA to a proviral DNA. We report a crystal structure of RT/dsDNA complex in which RT overstepped the primer 3’-end of a dsDNA substrate and created a transient P-pocket at the priming site. We performe...

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Detalles Bibliográficos
Autores principales: Singh, Abhimanyu K., Martinez, Sergio E., Gu, Weijie, Nguyen, Hoai, Schols, Dominique, Herdewijn, Piet, De Jonghe, Steven, Das, Kalyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654897/
https://www.ncbi.nlm.nih.gov/pubmed/34880240
http://dx.doi.org/10.1038/s41467-021-27409-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654897/
https://www.ncbi.nlm.nih.gov/pubmed/34880240
http://dx.doi.org/10.1038/s41467-021-27409-y

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