The PRY/SPRY domain of pyrin/TRIM20 interacts with β(2)-microglobulin to promote inflammasome formation

Pyrin/TRIM20 is expressed in the neutrophils and monocytes/macrophages and regulates caspase-1 activation and interleukin-1β maturation. Although the mutations in the PRY/SPRY domain of pyrin cause familial Mediterranean fever (FMF), the mechanism of how mutated pyrin provokes excessive inflammation...

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Detalles Bibliográficos
Autores principales: Samukawa, Sei, Yoshimi, Ryusuke, Kirino, Yohei, Nakajima, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654936/
https://www.ncbi.nlm.nih.gov/pubmed/34880353
http://dx.doi.org/10.1038/s41598-021-03073-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654936/
https://www.ncbi.nlm.nih.gov/pubmed/34880353
http://dx.doi.org/10.1038/s41598-021-03073-6

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