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Single-cell mapping of DNA G-quadruplex structures in human cancer cells

G-quadruplexes (G4s) are four-stranded DNA secondary structures that form in guanine-rich regions of the genome. G4s have important roles in transcription and replication and have been implicated in genome instability and cancer. Thus far most work has profiled the G4 landscape in an ensemble of cel...

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Detalles Bibliográficos
Autores principales: Hui, Winnie W. I., Simeone, Angela, Zyner, Katherine G., Tannahill, David, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654944/
https://www.ncbi.nlm.nih.gov/pubmed/34880271
http://dx.doi.org/10.1038/s41598-021-02943-3