Molecular basis for redox control by the human cystine/glutamate antiporter system xc(−)

Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring sp...

Descripción completa

Detalles Bibliográficos
Autores principales: Parker, Joanne L., Deme, Justin C., Kolokouris, Dimitrios, Kuteyi, Gabriel, Biggin, Philip C., Lea, Susan M., Newstead, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654953/
https://www.ncbi.nlm.nih.gov/pubmed/34880232
http://dx.doi.org/10.1038/s41467-021-27414-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654953/
https://www.ncbi.nlm.nih.gov/pubmed/34880232
http://dx.doi.org/10.1038/s41467-021-27414-1

Ejemplares similares