Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo and in cell models tha...

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Detalles Bibliográficos
Autores principales: Harding, Rachel J., Deme, Justin C., Hevler, Johannes F., Tamara, Sem, Lemak, Alexander, Cantle, Jeffrey P., Szewczyk, Magdalena M., Begeja, Nola, Goss, Siobhan, Zuo, Xiaobing, Loppnau, Peter, Seitova, Alma, Hutchinson, Ashley, Fan, Lixin, Truant, Ray, Schapira, Matthieu, Carroll, Jeffrey B., Heck, Albert J. R., Lea, Susan M., Arrowsmith, Cheryl H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654980/
https://www.ncbi.nlm.nih.gov/pubmed/34880419
http://dx.doi.org/10.1038/s42003-021-02895-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654980/
https://www.ncbi.nlm.nih.gov/pubmed/34880419
http://dx.doi.org/10.1038/s42003-021-02895-4

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