Structural basis for transthyretin amyloid formation in vitreous body of the eye

Amyloid transthyretin (ATTR) amyloidosis is characterized by the abnormal accumulation of ATTR fibrils in multiple organs. However, the structure of ATTR fibrils from the eye is poorly understood. Here, we used cryo-EM to structurally characterize vitreous body ATTR fibrils. These structures were di...

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Detalles Bibliográficos
Autores principales: Iakovleva, Irina, Hall, Michael, Oelker, Melanie, Sandblad, Linda, Anan, Intissar, Sauer-Eriksson, A. Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654999/
https://www.ncbi.nlm.nih.gov/pubmed/34880242
http://dx.doi.org/10.1038/s41467-021-27481-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654999/
https://www.ncbi.nlm.nih.gov/pubmed/34880242
http://dx.doi.org/10.1038/s41467-021-27481-4

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