Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

Transcriptional and cellular-stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal-dominant neurodegenerative disorder caused by a pathological expansion of CAG repeats in the Huntingtin (HTT) gene. The nucleolus, a dynamic nuclear biomolecular condensate and the...

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Detalles Bibliográficos
Autores principales: Sönmez, Aynur, Mustafa, Rasem, Ryll, Salome T., Tuorto, Francesca, Wacheul, Ludivine, Ponti, Donatella, Litke, Christian, Hering, Tanja, Kojer, Kerstin, Koch, Jenniver, Pitzer, Claudia, Kirsch, Joachim, Neueder, Andreas, Kreiner, Grzegorz, Lafontaine, Denis L. J., Orth, Michael, Liss, Birgit, Parlato, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655027/
https://www.ncbi.nlm.nih.gov/pubmed/34880223
http://dx.doi.org/10.1038/s41419-021-04432-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655027/
https://www.ncbi.nlm.nih.gov/pubmed/34880223
http://dx.doi.org/10.1038/s41419-021-04432-x

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